Blar i forfatter "Kruse, Larissa Dorothea"

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    • Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure 

      Mao, Hong; Szafranska, Karolina; Kruse, Larissa Dorothea; Holte, Christopher Florian; Wolfson, Deanna; Ahluwalia, Balpreet Singh; Whitchurch, Cynthia B.; Cole, Louise; Lockwood, Glen P.; Diekmann, Robin; Le Couteur, David; Cogger, Victoria C.; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-17)
      Xanthines such as caffeine and theobromine are among the most consumed psychoactive stimulants in the world, either as natural components of cofee, tea and chocolate, or as added ingredients. The present study assessed if xanthines affect liver sinusoidal endothelial cells (LSEC). Cultured primary rat LSEC were challenged with xanthines at concentrations typically obtained from normal consumption of ...

    • Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2 

      Holte, Christopher Florian; Szafranska, Karolina Joanna; Kruse, Larissa Dorothea; Simon-Santamaria, Jaione; Li, Ruomei; Svistounov, Dmitri; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-05)
      Oxidized albumin (oxHSA) is elevated in several pathological conditions, such as decompensated cirrhosis, acute on chronic liver failure and liver mediated renal failure. Patient derived oxidized albumin was previously shown to be an infammatory mediator, and in normal serum levels of oxHSA are low. The removal from circulation of oxidized albumins is therefore likely required for maintenance of ...

    • Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study 

      Szafranska, Karolina; Holte, Christopher Florian; Kruse, Larissa Dorothea; Mao, Hong; Øie, Cristina Ionica; Symonski, Marek; Zapotoczny, Bartlomiej; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)
      Liver Sinusoidal Endothelial Cells (LSEC) line the hepatic vasculature providing blood filtration via transmembrane nanopores called fenestrations. These structures are 50−300 nm in diameter, which is below the resolution limit of a conventional light microscopy. To date, there is no standardized method of fenestration image analysis. With this study, we provide and compare three different approaches: ...